Signaling pathways altered at the mitotic spindle in clathrin depleted cells
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Permanent Cell Line Cell
DISEASE(S): Cancer
SUBMITTER: 
Sushma Rao
LAB HEAD: A/Prof. Megan Chircop
PROVIDER: PXD001603 | Pride | 2016-05-17
REPOSITORIES: Pride
Publications
The Clathrin-dependent Spindle Proteome.
Rao Sushma R SR Flores-Rodriguez Neftali N Page Scott L SL Wong Chin C Robinson Phillip J PJ Chircop Megan M
Molecular & cellular proteomics : MCP 20160512 8
The mitotic spindle is required for chromosome congression and subsequent equal segregation of sister chromatids. These processes involve a complex network of signaling molecules located at the spindle. The endocytic protein, clathrin, has a "moonlighting" role during mitosis, whereby it stabilizes the mitotic spindle. The signaling pathways that clathrin participates in to achieve mitotic spindle stability are unknown. Here, we assessed the mitotic spindle proteome and phosphoproteome in clathr ...[more]
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