Quantitative phosphoproteome of ecto-ATP synthase blockade in lung cancer cells

ABSTRACT: ATP synthase is crucial for ATP synthesis in living cells. Recently, ATP synthase was found not only in mitochondria but also on the extracellular surface, named as ectopic ATP synthase (ecto-ATP synthase). ATP synthase inhibitor is a potential drug candidate to fight cancer by blocking the ecto-ATP synthase of cancer cells. In this study, we applied dynamic phosphoproteomics to elucidate the molecular responses to ecto-ATP synthase blockade.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

DISEASE(S): Lung Adenocarcinoma

SUBMITTER: Chia-Wei Hu  

LAB HEAD: Hsueh-Fen Juan

PROVIDER: PXD000696 | Pride | 2015-11-06

REPOSITORIES: Pride