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Phosphoproteome characterization of Sendai-virus infection in human epithelial cells

ABSTRACT: We used phosphoproteomics combined with bioinformatics to characterize the global cellular protein phosphorylation events during Sendai virus infection in human lung epithelial cells.

INSTRUMENT(S): QSTAR

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

SUBMITTER: Tuula Nyman

LAB HEAD: Tuula Nyman

PROVIDER: PXD001561 | Pride | 2015-03-17

REPOSITORIES: Pride

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Phosphoproteome characterization reveals that Sendai virus infection activates mTOR signaling in human epithelial cells.

Öhman Tiina T Söderholm Sandra S Paidikondala Maruthibabu M Lietzén Niina N Matikainen Sampsa S Nyman Tuula A TA

Proteomics 20150427 12

Sendai virus (SeV) is a common respiratory pathogen in mice, rats, and hamsters. Host cell recognition of SeV is mediated by pathogen recognition receptors, which recognize viral components and induce intracellular signal transduction pathways that activate the antiviral innate immune response. Viruses use host proteins to control the activities of signaling proteins and their downstream targets, and one of the most important host protein modifications regulated by viral infection is phosphoryla ...[more]

PMID: 25764225

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