Clamping down on transcription: repression of archaeal RNAP by the novel viral regulator RIP

ABSTRACT: Little is known about how archaeal viruses perturbate the transcription machinery of their hosts. We provide the first example of a non-DNA binding archaeo-viral transcription factor that directly targets the host RNA polymerase and efficiently represses its activity. We have used cross-linking and mass spectrometry to identify how ORF145 binds in the DNA-binding channel of RNA polymerase.

INSTRUMENT(S):

ORGANISM(S): Sulfolobus Solfataricus

SUBMITTER: Adam Belsom  

LAB HEAD: Juri Rappsilber

PROVIDER: PXD003282 | Pride | 2016-12-02

REPOSITORIES: Pride