Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture, Fibroblast
DISEASE(S): Neck Carcinoma
SUBMITTER: Luc Camoin
LAB HEAD: Luc Camoin
PROVIDER: PXD003457 | Pride | 2016-12-24
REPOSITORIES: Pride
Gopal Sandeep S Veracini Laurence L Grall Dominique D Butori Catherine C Schaub Sébastien S Audebert Stéphane S Camoin Luc L Baudelet Emilie E Radwanska Agata A Beghelli-de la Forest Divonne Stéphanie S Violette Shelia M SM Weinreb Paul H PH Rekima Samah S Ilie Marius M Sudaka Anne A Hofman Paul P Van Obberghen-Schilling Ellen E
Nature communications 20170119
Functional interplay between tumour cells and their neoplastic extracellular matrix plays a decisive role in malignant progression of carcinomas. Here we provide a comprehensive data set of the human HNSCC-associated fibroblast matrisome. Although much attention has been paid to the deposit of collagen, we identify oncofetal fibronectin (FN) as a major and obligate component of the matrix assembled by stromal fibroblasts from head and neck squamous cell carcinomas (HNSCC). FN overexpression in t ...[more]