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Mouse_T1D_microbiota - Clostridial Butyrate Biosynthesis Enzymes Are Significantly Depleted in the Gut Microbiota of Nonobese Diabetic Mice

ABSTRACT: A metaproteomic approach was exploited to investigate microbiota protein expression in feces from Eα16 and NOD mice at 10 weeks of age (n=6 vs 6 mice)

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Gut Metagenome Mus Musculus (mouse)

TISSUE(S): Feces

DISEASE(S): Type 1 Diabetes Mellitus

SUBMITTER: Alessandro Tanca

LAB HEAD: Sergio Uzzau

PROVIDER: PXD003616 | Pride | 2018-10-15

REPOSITORIES: Pride

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Clostridial Butyrate Biosynthesis Enzymes Are Significantly Depleted in the Gut Microbiota of Nonobese Diabetic Mice.

Tanca Alessandro A Palomba Antonio A Fraumene Cristina C Manghina Valeria V Silverman Michael M Uzzau Sergio S

mSphere 20181024 5

Increasing evidence suggests that the intestinal microbiota is involved in the pathogenesis of type 1 diabetes (T1D). Here we sought to determine which gut microbial taxa and functions vary between nonobese diabetic (NOD) mice and genetically modified NOD mice protected from T1D (Eα16/NOD) at 10 weeks of age in the time window between insulitis development and T1D onset. The gut microbiota of NOD mice were investigated by analyzing stool samples with a metaproteogenomic approach, comprising both ...[more]

PMID: 30355671

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