Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Guillaume Arras
LAB HEAD: Damarys Loew
PROVIDER: PXD004099 | Pride | 2016-06-14
REPOSITORIES: Pride
Prendergast Lisa L Müller Sebastian S Liu Yiwei Y Huang Hongda H Dingli Florent F Loew Damarys D Vassias Isabelle I Patel Dinshaw J DJ Sullivan Kevin F KF Almouzni Geneviève G
Genes & development 20160609 11
The CENP-T/-W histone fold complex, as an integral part of the inner kinetochore, is essential for building a proper kinetochore at the centromere in order to direct chromosome segregation during mitosis. Notably, CENP-T/-W is not inherited at centromeres, and new deposition is absolutely required at each cell cycle for kinetochore function. However, the mechanisms underlying this new deposition of CENP-T/-W at centromeres are unclear. Here, we found that CENP-T deposition at centromeres is unco ...[more]