Dataset Information


Quantitative proteomic and phosphoproteomic analysis of H37Ra and H37Rv strains of Mycobacterium tuberculosis

ABSTRACT: Mycobacterium tuberculosis, the causative agent of tuberculosis accounts for 1.5 million annual deaths worldwide. The two well-characterized strains of the parental H37 strain namely, H37Ra and H37Rv show different pathogenic phenotypes. In order to identify factors that are responsible for virulence, we compared the proteome and the phosphoproteome profiles of virulent (H37Rv) and virulence attenuated (H37Ra) strains of M. tuberculosis. Quantitative proteomic analysis resulted in the identification and quantitation of 2,709 proteins and 505 phosphosites. Comparative analysis revealed over 5-fold overexpression of several proteins associated with virulence. Our data indicates that there are definable molecular differences between H37Rv and H37Ra strains at both the proteome and phosphoproteome levels which may explain the virulence and phenotypic differences.


ORGANISM(S): Mycobacterium Tuberculosis

DISEASE(S): Tuberculosis

SUBMITTER: Keshava Prasad T. S.  

LAB HEAD: Keshava Prasad T.S.

PROVIDER: PXD004161 | Pride | 2017-05-08


Dataset's files

Action DRS
RaRv_Phospho.msf Msf
RaRv_Phospho.pep.xml Pepxml
RaRv_Phospho.prot.xml Xml
RaRv_Phospho_1.raw Raw
RaRv_Phospho_10.raw Raw
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Mycobacterium tuberculosis, the causative agent of tuberculosis, accounts for 1.5 million human deaths annually worldwide. Despite efforts to eradicate tuberculosis, it still remains a deadly disease. The two best characterized strains of M. tuberculosis, virulent H37Rv and avirulent H37Ra, provide a unique platform to investigate biochemical and signaling pathways associated with pathogenicity. To delineate the biomolecular dynamics that may account for pathogenicity and attenuation of virulenc  ...[more]

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