Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA326271
INSTRUMENT(S): LTQ Orbitrap XL
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): B Cell, B-lymphoma Cell Line
DISEASE(S): Chronic Lymphocytic Leukemia
SUBMITTER: Murat Iskar
LAB HEAD: Martina Seiffert
PROVIDER: PXD004420 | Pride | 2017-08-09
REPOSITORIES: Pride
Haderk Franziska F Schulz Ralph R Iskar Murat M Cid Laura Llaó LL Worst Thomas T Willmund Karolin V KV Schulz Angela A Warnken Uwe U Seiler Jana J Benner Axel A Nessling Michelle M Zenz Thorsten T Göbel Maria M Dürig Jan J Diederichs Sven S Paggetti Jérôme J Moussay Etienne E Stilgenbauer Stephan S Zapatka Marc M Lichter Peter P Seiffert Martina M
Science immunology 20170701 13
In chronic lymphocytic leukemia (CLL), monocytes and macrophages are skewed toward protumorigenic phenotypes, including the release of tumor-supportive cytokines and the expression of immunosuppressive molecules such as programmed cell death 1 ligand 1 (PD-L1). To understand the mechanism driving protumorigenic skewing in CLL, we evaluated the role of tumor cell-derived exosomes in the cross-talk with monocytes. We carried out RNA sequencing and proteome analyses of CLL-derived exosomes and iden ...[more]