Proteomics

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Identification of HLA-B*57:01-restricted endogenous and HIV epitopes

ABSTRACT: A novel modified HLA-B*57:01-restricted epitope was identified in one of the reversed-phase fractions following immunoaffinity purification of HLA-peptide complexes from C1R cells expressing HIV envelope protein. Also includes six immunopeptidome datasets from several B57 and env transfected cell lysates.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human) Hiv-1 M:b_hxb2r

TISSUE(S): B Cell, Cell Suspension Culture

SUBMITTER: Sri Ramarathinam  

LAB HEAD: Anthony Purcell

PROVIDER: PXD004471 | Pride | 2018-02-19

REPOSITORIES: Pride

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Publications

The recognition of pathogen-derived peptides by T lymphocytes is the cornerstone of adaptive immunity, whereby intracellular antigens are degraded in the cytosol and short peptides assemble with class I human leukocyte antigen (HLA) molecules in the ER. These peptide-HLA complexes egress to the cell surface and are scrutinized by cytotoxic CD8+ T-cells leading to the eradication of the infected cell. Here, naturally presented HLA-B*57:01 bound peptides derived from the envelope protein of the hu  ...[more]

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