Ontology highlight
ABSTRACT:
INSTRUMENT(S): TripleTOF 5600, Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Blood Cell, Cell Culture
DISEASE(S): Disease Free
SUBMITTER: Pouya Faridi
LAB HEAD: Anthony Purcell
PROVIDER: PXD017922 | Pride | 2021-12-06
REPOSITORIES: Pride
Science immunology 20181001 28
The diversity of peptides displayed by class I human leukocyte antigen (HLA) plays an essential role in T cell immunity. The peptide repertoire is extended by various posttranslational modifications, including proteasomal splicing of peptide fragments from distinct regions of an antigen to form nongenomically templated cis-spliced sequences. Previously, it has been suggested that a fraction of the immunopeptidome constitutes such cis-spliced peptides; however, because of computational limitation ...[more]