Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human) Hiv-1 Vector Pnl4-3
TISSUE(S): Cell Suspension Culture, T Cell, Leukocyte, Cell Culture
DISEASE(S): Acquired Immunodeficiency Syndrome
SUBMITTER: Nicola Ternette
LAB HEAD: Nicola Ternette
PROVIDER: PXD015489 | Pride | 2019-11-25
REPOSITORIES: Pride
Proceedings of the National Academy of Sciences of the United States of America 20191120 49
Peptides generated by proteasome-catalyzed splicing of noncontiguous amino acid sequences have been shown to constitute a source of nontemplated human leukocyte antigen class I (HLA-I) epitopes, but their role in pathogen-specific immunity remains unknown. CD8<sup>+</sup> T cells are key mediators of HIV type 1 (HIV-1) control, and identification of novel epitopes to enhance targeting of infected cells is a priority for prophylactic and therapeutic strategies. To explore the contribution of prot ...[more]