Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Nicola Ternette
LAB HEAD: Dr Nicola Ternette
PROVIDER: PXD021339 | Pride | 2020-10-26
REPOSITORIES: Pride
Paes Wayne W Leonov German G Partridge Thomas T Nicastri Annalisa A Ternette Nicola N Borrow Persephone P
Frontiers in immunology 20200924
Proteasomes catalyze the degradation of endogenous proteins into oligopeptides, but can concurrently create spliced oligopeptides through ligation of previously non-contiguous peptide fragments. Recent studies have uncovered a formerly unappreciated role for proteasome-catalyzed peptide splicing (PCPS) in the generation of non-genomically templated human leukocyte antigen class I (HLA-I)-bound <i>cis-</i>spliced peptides that can be targeted by CD8<sup>+</sup> T cells in cancer and infection. Ho ...[more]