Proteomics

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Impact of abacavir and abacavir analogues on HLA-B*57:01 peptide presentation

ABSTRACT: Characterisation of peptide ligands of the Major histocompatibility class (MHC) I allele, HLA-B*57:01, expressed in the C1R (Class I reduced) B-lymphoblastoid cell line, after exposure to the anti-retroviral abacavir or abacavir analogues.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Suspension Culture

SUBMITTER: Patricia Illing  

LAB HEAD: Anthony W. Purcell

PROVIDER: PXD015398 | Pride | 2019-10-03

REPOSITORIES: Pride

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Publications

Modification of the cyclopropyl moiety of abacavir provides insight into the structure activity relationship between HLA-B*57:01 binding and T-cell activation.

Thomson Paul J PJ   Illing Patricia T PT   Farrell John J   Alhaidari Mohammad M   Bell Catherine C CC   Berry Neil N   O'Neill Paul M PM   Purcell Anthony W AW   Park Kevin B KB   Naisbitt Dean J DJ  

Allergy 20191009 3

<h4>Background</h4>Abacavir is associated with hypersensitivity reactions in individuals positive for the HLA-B*57:01 allele. The drug binds within the peptide binding groove of HLA-B*57:01 altering peptides displayed on the cell surface. Presentation of these HLA-abacavir-peptide complexes to T-cells is hypothesized to trigger a CD8<sup>+</sup> T-cell response underpinning the hypersensitivity. Thus, the aim of this study was to explore the relationship between the structure of abacavir with HL  ...[more]

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