Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Permanent Cell Line Cell, Cell Culture
SUBMITTER: Ivo Hendriks
LAB HEAD: Michael Lund Nielsen
PROVIDER: PXD004927 | Pride | 2017-01-24
REPOSITORIES: Pride
Hendriks Ivo A IA Lyon David D Young Clifford C Jensen Lars J LJ Vertegaal Alfred C O AC Nielsen Michael L ML
Nature structural & molecular biology 20170123 3
Small ubiquitin-like modifiers (SUMOs) are post-translational modifications (PTMs) that regulate nuclear cellular processes. Here we used an augmented K0-SUMO proteomics strategy to identify 40,765 SUMO acceptor sites and quantify their fractional contribution for 6,747 human proteins. Structural-predictive analyses revealed that lysines residing in disordered regions are preferentially targeted by SUMO, in notable contrast to other widespread lysine modifications. In our data set, we identified ...[more]