Re-examining the role of Cdc14 phosphatase in mitotic exit

ABSTRACT: Given that Cdc14 enzymes are so highly conserved, we questioned whether budding yeast Cdc14 could really have such a different influence on Cdk site dephosphorylation. We used quantitative phosphoproteomics to directly measure the in vivo specificity of budding yeast Cdc14 and found that it very selectively dephosphorylates a distinct sub-class of Cdk sites and does not catalyze widespread Cdk site dephosphorylation as widely believed.

INSTRUMENT(S):

ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast)

SUBMITTER: Brendan Powers  

LAB HEAD: Mark Hall

PROVIDER: PXD005237 | Pride | 2017-07-13

REPOSITORIES: Pride