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Equine CD4+ T cells show changed membrane protein expression in autoimmune uveitis

ABSTRACT: Through this comparative proteomic study of equine CD4+ cells 376 membrane proteins could be identified. Several proteins showed changed abundance in horses affected by a spontaneous autoimmune disease (equine recurrent uveitis, ERU). Findings provide novel knowledge about changes in the CD4+ immune cell membrane proteome in a spontaneously and naturally occurring autoimmune disease in horses. The data is highly relevant for veterinary medicine and has proven translational quality for autoimmune uveitis in man.

INSTRUMENT(S): LTQ Orbitrap XL

ORGANISM(S): Equus Caballus (horse)

TISSUE(S): Primary Cell, T Cell

DISEASE(S): Uveitis,Autoimmune Disease Of Eyes

SUBMITTER: Roxane Degroote

LAB HEAD: Cornelia Annette Deeg

PROVIDER: PXD005384 | Pride | 2017-01-09

REPOSITORIES: Pride

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Formin like 1 expression is increased on CD4+ T lymphocytes in spontaneous autoimmune uveitis.

Degroote Roxane L RL Uhl Patrizia B PB Amann Barbara B Krackhardt Angela M AM Ueffing Marius M Hauck Stefanie M SM Deeg Cornelia A CA

Journal of proteomics 20170103

The membrane protein expression repertoire of cells changes in course of activation. In equine recurrent uveitis (ERU), a spontaneous autoimmune disease in horses with relapsing and ultimately blinding inner eye inflammation, CD4+ T lymphocytes are the crucial pathogenic cells activated in the periphery directly prior to an inflammatory episode. In order to find relevant changes in the membrane proteome associated to disease, we sorted CD4+ lymphocytes and compared protein abundance from the gen ...[more]

PMID: 28057602

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