Equine CD4+ T cells show changed membrane protein expression in autoimmune uveitis

ABSTRACT: Through this comparative proteomic study of equine CD4+ cells 376 membrane proteins could be identified. Several proteins showed changed abundance in horses affected by a spontaneous autoimmune disease (equine recurrent uveitis, ERU). Findings provide novel knowledge about changes in the CD4+ immune cell membrane proteome in a spontaneously and naturally occurring autoimmune disease in horses. The data is highly relevant for veterinary medicine and has proven translational quality for autoimmune uveitis in man.

INSTRUMENT(S):

ORGANISM(S): Equus Caballus (horse)

TISSUE(S): Primary Cell, T Cell

DISEASE(S): Uveitis,Autoimmune Disease Of Eyes

SUBMITTER: Roxane Degroote  

LAB HEAD: Cornelia Annette Deeg

PROVIDER: PXD005384 | Pride | 2017-01-09

REPOSITORIES: Pride