Proteomics

Dataset Information

0

Analysis of phosphorylation sites in CLL samples


ABSTRACT: The profiling of B-cell chronic lymphocytic leukemia (B-CLL) cells at the protein level is still a major goal for advancing targeted personalized therapies. Understanding how B cells become malignant would be supported by the description of predicted responses to kinase inhibitors as nearly all cancers are guided by deregulation of protein kinase networks. In this sense, the present project looks for the profiling of the phosphopetides present in the B-CLL proteins together with the full characterization of their proteome.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): B Cell, Blood

DISEASE(S): Chronic Lymphocytic Leukemia

SUBMITTER: Paula Díez  

LAB HEAD: Manuel Fuentes

PROVIDER: PXD005997 | Pride | 2025-05-13

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
Sample_A1_PTM.pep.xml Pepxml
Sample_A1_PTM.raw Raw
Sample_A1_proteome.pep.xml Pepxml
Sample_A1_proteome.raw Raw
Sample_A2_PTM.pep.xml Pepxml
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Publications


B-cell chronic lymphocytic leukemia (B-CLL) is characterized by highly heterogeneous genomic alterations and altered signaling pathways, with limited studies on its proteome. Our study presents a comprehensive analysis of the proteome and phosphoproteome in B-CLL and CLL-like monoclonal B-cell lymphocytosis (MBL) primary cells. Using high-resolution mass spectrometry, we identified 2970 proteins and 316 phosphoproteins across five tumor samples, including 55 newly identified phosphopeptides (Pro  ...[more]

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