Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Plasmodium Falciparum Homo Sapiens (human)
SUBMITTER: Steven Batinovic
LAB HEAD: Leann Tilley
PROVIDER: PXD006155 | Pride | 2017-07-13
REPOSITORIES: Pride
Batinovic Steven S McHugh Emma E Chisholm Scott A SA Matthews Kathryn K Liu Boiyin B Dumont Laure L Charnaud Sarah C SC Schneider Molly Parkyn MP Gilson Paul R PR de Koning-Ward Tania F TF Dixon Matthew W A MWA Tilley Leann L
Nature communications 20170710
The malaria parasite, Plasmodium falciparum, displays the P. falciparum erythrocyte membrane protein 1 (PfEMP1) on the surface of infected red blood cells (RBCs). We here examine the physical organization of PfEMP1 trafficking intermediates in infected RBCs and determine interacting partners using an epitope-tagged minimal construct (PfEMP1B). We show that parasitophorous vacuole (PV)-located PfEMP1B interacts with components of the PTEX (Plasmodium Translocon of EXported proteins) as well as a ...[more]