Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane

ABSTRACT: Sulforaphane is a small molecule isothiocyanate which exhibits anticancer potential, yet its biological targets remain poorly understood. Here we employ a competition-based chemical proteomics strategy to profile sulforaphane’s targets and identify over 500 targets along with their relative affinities. These targets provide a new set of mediators for sulforaphane’s bioactivity, and aid understanding of its complex mode of action.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

DISEASE(S): Breast Cancer

SUBMITTER: Thomas Lanyon-Hogg  

LAB HEAD: Edward Tate

PROVIDER: PXD006279 | Pride | 2017-05-24

REPOSITORIES: Pride