Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
DISEASE(S): Breast Cancer
SUBMITTER: Thomas Lanyon-Hogg
LAB HEAD: Edward Tate
PROVIDER: PXD006279 | Pride | 2017-05-24
REPOSITORIES: Pride
Clulow James A JA Storck Elisabeth M EM Lanyon-Hogg Thomas T Kalesh Karunakaran A KA Jones Lyn H LH Tate Edward W EW
Chemical communications (Cambridge, England) 20170501 37
Sulforaphane is a small molecule isothiocyanate which exhibits anticancer potential, yet its biological targets remain poorly understood. Here we employ a competition-based chemical proteomics strategy to profile sulforaphane's targets and identify over 500 targets along with their relative affinities. These targets provide a new set of mediators for sulforaphane's bioactivity, and aid understanding of its complex mode of action. ...[more]