Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos, LTQ Orbitrap Elite
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): T Cell, Blood
SUBMITTER: Niclas Olsson
LAB HEAD: Joshua E Elias
PROVIDER: PXD007860 | Pride | 2018-03-08
REPOSITORIES: Pride
Olsson Niclas N Schultz Liora M LM Zhang Lichao L Khodadoust Michael S MS Narayan Rupa R Czerwinski Debra K DK Levy Ronald R Elias Joshua E JE
Proteomics 20180418 12
Immunopeptidomes promise novel surface markers as ideal immunotherapy targets, but their characterization by mass spectrometry (MS) remains challenging. Until recently, cell numbers exceeding 10<sup>9</sup> were needed to survey thousands of HLA ligands. Such limited analytical sensitivity has historically constrained the types of clinical specimens that can be evaluated to cell cultures or bulk tissues. Measuring immunopeptidomes from purified cell subpopulations would be preferable for many ap ...[more]