Proteomics

Dataset Information

28

Cdc42 phosphorylation study - Cdc42 Regulates Neuronal Polarity during Cerebellar Axon Formation and Glial-Guided Migration


ABSTRACT: Govek et al. demonstrate conditional loss of Cdc42 in cerebellar granule cell progenitors (GCPs) perturbs GCP polarity and impairs axon patterning, glial-guided migration, and cerebellar foliation. Phospho-proteomic analysis identified polarity and cytoskeletal proteins as affected targets in Cdc42 deficient GCPs.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Mus musculus  

TISSUE(S): Brain

DISEASE(S): Not Available

SUBMITTER: henrik molina  

LAB HEAD: Mary E. Hatten

PROVIDER: PXD008148 | Pride | 2018-10-22

REPOSITORIES: Pride

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Publications

Cdc42 Regulates Neuronal Polarity during Cerebellar Axon Formation and Glial-Guided Migration.

Govek Eve-Ellen EE   Wu Zhuhao Z   Acehan Devrim D   Molina Henrik H   Rivera Keith K   Zhu Xiaodong X   Fang Yin Y   Tessier-Lavigne Marc M   Hatten Mary Elizabeth ME  

iScience 20180301


CNS cortical histogenesis depends on polarity signaling pathways that regulate cell adhesion and motility. Here we report that conditional deletion of the Rho GTPase Cdc42 in cerebellar granule cell precursors (GCPs) results in abnormalities in cerebellar foliation revealed by iDISCO clearing methodology, a loss of columnar organization of proliferating GCPs in the external germinal layer (EGL), disordered parallel fiber organization in the molecular layer (ML), and a failure to extend a leading  ...[more]

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