Proteomics

Dataset Information

0

Pseudomonas fluorescens LC-MSMS


ABSTRACT: our work revealed a rewired regulatory network of mqsA in P. fluoresces, in which a new transcription factor is recruited and incorporated to fulfill the similar physiological function.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Pseudomonas Fluorescens F113

TISSUE(S): Sperm, Whole Body

DISEASE(S): Wounds And Injuries

SUBMITTER: Meng-Yuan Zhang  

LAB HEAD: Zhang-Meng Yuan

PROVIDER: PXD008578 | Pride | 2019-01-30

REPOSITORIES: Pride

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Publications

The antitoxin MqsA homologue in Pseudomonas fluorescens 2P24 has a rewired regulatory circuit through evolution.

Wang Yong Y   Zhang Si-Ping SP   Zhang Meng-Yuan MY   Kempher Megan L ML   Guo Ding-Ding DD   Han Jian-Ting JT   Tao Xuanyu X   Wu Yi Y   Zhang Li-Qun LQ   He Yong-Xing YX  

Environmental microbiology 20190321 5


The mqsRA operon encodes a toxin-antitoxin pair that was characterized to participate in biofilm and persister cell formation in Escherichia coli. Notably, the antitoxin MqsA possesses a C-terminal DNA-binding domain that recognizes the [5'-AACCT(N)<sub>2-4</sub> AGGTT-3'] motif and acts as a transcriptional regulator controlling multiple genes including the general stress response regulator RpoS. However, it is unknown how the transcriptional circuits of MqsA homologues have changed in bacteria  ...[more]

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