Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Heart
SUBMITTER: Paul Grimsrud
LAB HEAD: Matthew D. Hirschey
PROVIDER: PXD008728 | Pride | 2018-05-16
REPOSITORIES: Pride
Hershberger Kathleen A KA Abraham Dennis M DM Liu Juan J Locasale Jason W JW Grimsrud Paul A PA Hirschey Matthew D MD
The Journal of biological chemistry 20180516 27
Mitochondrial Sirtuin 5 (SIRT5) is an NAD<sup>+</sup>-dependent demalonylase, desuccinylase, and deglutarylase that controls several metabolic pathways. A number of recent studies point to SIRT5 desuccinylase activity being important in maintaining cardiac function and metabolism under stress. Previously, we described a phenotype of increased mortality in whole-body SIRT5KO mice exposed to chronic pressure overload compared with their littermate WT controls. To determine whether the survival phe ...[more]