Proteomics

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IgG-independent co-aggregation of FceRI and FcgRIIB results in LYN- and SHIP1-dependent tyrosine phosphorylation of FcgRIIB

ABSTRACT: We used tyrosine phosphorylation profiling by anti-pTyr-antibody mediated enrichment and subsequent analysis by mass spectrometry in order to determine the changes in early signalling after mast cell activation. Mast cells were stimulated with varying concentrations of antigen for one minute and the differences between optimal (20 ng/ml) and supra-optimal (2000 ng/ml) antigen mast cell activation were analysed by nanoLC-MS/MS.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Mast Cell, Bone Marrow

SUBMITTER: Christian Preisinger  

LAB HEAD: Michael Huber

PROVIDER: PXD009318 | Pride | 2018-08-17

REPOSITORIES: Pride

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Dataset's files

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Action DRS
OR1_2017_10_03_MG_3rd_pY_BMMC1_170316152555.raw Raw
OR1_2017_10_03_MG_3rd_pY_BMMC2.raw Raw
OR1_MG2_pY_MCtriple1.raw Raw
OR1_MG2_pY_MCtriple2.raw Raw
OR1_MG_pY_MCtriple1.raw Raw
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