Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Mast Cell, Bone Marrow
SUBMITTER: Christian Preisinger
LAB HEAD: Michael Huber
PROVIDER: PXD009318 | Pride | 2018-08-17
REPOSITORIES: Pride
Gast Mathias M Preisinger Christian C Nimmerjahn Falk F Huber Michael M
Frontiers in immunology 20180827
Activation of the high-affinity receptor for IgE (FcεRI) follows a bell-shaped dose-response curve. Upon supra-optimal stimulation, mast cell effector responses are down-regulated by inhibitory molecules like the SH2-containing inositol-5'-phosphatase SHIP1 and the SRC-family-kinase LYN. To identify further molecules involved in a negative regulatory signalosome, we screened for proteins showing the same pattern of tyrosine phosphorylation as SHIP1, which is tyrosine-phosphorylated strongest upo ...[more]