Quantitative phosphoproteomic for CDKL5 substrates

ABSTRACT: Global phosphoproteomic screen to identify the first cellular substrates of CDKL5. CDKL5 knock-out U2OS cells and CDKL5 wt U2OS cells were generated for the TMT-based phosphoproteomic. Thi leads to the identification and further validation of several phosphopetides of MAP1S, CEP131 and CDKL5 itself. The phosphoproteomic analysis allowed the identification of the first cellular substrates for CDKL5 kinase.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

DISEASE(S): Brain Disease

SUBMITTER: Matthias Trost  

LAB HEAD: Matthias Trost

PROVIDER: PXD009374 | Pride | 2018-09-24

REPOSITORIES: Pride