Proteomics

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Protemic analysis of the effect of c-di-GMP and c-di-AMP on the protein expression of Mycobacterium smegmatis


ABSTRACT: c-di-GMP and c-di-AMP are important conserved second messenger in bacteria, they play a critical role in a wide range of cellular processes, such as motility, virulence, biofilm formation, cell-cycle progression and cell development, but there are only two c-di-GMP receptors and one c-di-AMP receptors were identified in mycobacteria so far, to identify more c-di-GMP and c-di-AMP receptors we compare the protein expression level of c-di-GMP or c-di-AMP synthesis enzyme overexpression strain with the wild type Mycobacterium smegmatis.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Mycobacterium Smegmatis (strain Atcc 700084 / Mc(2)155)

SUBMITTER: Qingbin Hu  

LAB HEAD: Zheng-Guo He

PROVIDER: PXD010623 | Pride | 2019-07-03

REPOSITORIES: Pride

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Publications

Cyclic di-GMP co-activates the two-component transcriptional regulator DevR in <i>Mycobacterium smegmatis</i> in response to oxidative stress.

Hu Qingbin Q   Zhang Jiaxun J   Chen Yu Y   Hu Lihua L   Li Weihui W   He Zheng-Guo ZG  

The Journal of biological chemistry 20190703 34


Cyclic di-GMP (c-di-GMP) is an important second messenger in bacteria, and its regulatory network has been extensively studied. However, information regarding the activation mechanisms of its receptors remains limited. In this study, we characterized the two-component regulator DevR as a new c-di-GMP receptor and further uncovered a novel co-activation mechanism for effective regulation of DevR in mycobacteria. We show that high c-di-GMP levels induce the expression of the <i>devR</i> operon in  ...[more]

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