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Human Platelets PRM - A high glucose level is associated with decreased aspirin-mediated acetylation of platelet cyclooxygenase (COX)-1 at serine 529: A pilot study

ABSTRACT: The main aim of this study is to decipher the mutual impact that high glucose levels and diabetes have on aspirin-mediated acetylation of COX-1 through a targeted parallel reaction monitoring MS approach.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Platelet, Platelet

DISEASE(S): Type 2 Diabetes Mellitus

SUBMITTER: Francesco Finamore

LAB HEAD: Jean-Charles Sanchez

PROVIDER: PXD011204 | Pride | 2018-10-10

REPOSITORIES: Pride

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	20160307_QE307.raw	Raw
	20160307_QE308.raw	Raw
	20160307_QE309.raw	Raw
	20160307_QE311.raw	Raw
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A high glucose level is associated with decreased aspirin-mediated acetylation of platelet cyclooxygenase (COX)-1 at serine 529: A pilot study.

Finamore Francesco F Reny Jean-Luc JL Malacarne Sarah S Fontana Pierre P Sanchez Jean-Charles JC

Journal of proteomics 20180918

Diabetes is a major risk factor for cardiovascular diseases. Although aspirin is considered a cornerstone of the prevention and treatment of atherothrombotic-related ischemic events, this antiplatelet drug appears to be less effective in patients with poorly controlled diabetes. It has been suggested that the glycation of platelet proteins plays a pivotal role in poor responsiveness to aspirin. However, a direct effect on the critical residue (serine 529, or Ser 529) of the catalytic pocket of c ...[more]

PMID: 30240925

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