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Two of a kind: Transmissible Schwann cell cancers in the endangered Tasmanian devil.

ABSTRACT: Devil facial tumour disease 1 and 2 (DFT1 and DFT2) are two genetically distinct transmissible cancers endangering the survival of the Tasmanian devil (Sarcophilus harrisii). DFT1 first arose from a cell of the Schwann cell lineage, however, the tissue-of-origin of the recently discovered DFT2 cancer remains unknown. Here we have performed mRNA and protein expression analyses to show that variation in expression patterns between DFT1 and DFT2 tumours is low. Furthermore, DFT2 cells express a range of markers associated with Schwann cell differentiation, suggesting a similar tissue-of-origin to DFT1 tumours. These findings suggest that devils may be predisposed to transmissible cancers of Schwann cell origin. The emergence of these two unique cancers presents an unprecedented opportunity to gain insight into cancer development in animal species.

INSTRUMENT(S): TripleTOF 6600

ORGANISM(S): Sarcophilus Harrisii

TISSUE(S): Cell Culture, Fibroblast

SUBMITTER: Karthik Shantharam kamath

LAB HEAD: Amanda L Patchett

PROVIDER: PXD011209 | Pride | 2019-08-06

REPOSITORIES: Pride

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