Proteomics-based identification of SIRT2 interaction partners
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive Plus
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Hela Cell
SUBMITTER: 
Impens Francis
LAB HEAD: Mélanie Hamon
PROVIDER: PXD011523 | Pride | 2020-02-20
REPOSITORIES: Pride
Publications
Active nuclear import of the deacetylase Sirtuin-2 is controlled by its C-terminus and importins.
Eldridge Matthew J G MJG Pereira Jorge M JM Impens Francis F Hamon Mélanie A MA
Scientific reports 20200210 1
The NAD-dependent deacetylase Sirtuin-2 (SIRT2) functions in diverse cellular processes including the cell cycle, metabolism, and has important roles in tumorigenesis and bacterial infection. SIRT2 predominantly resides in the cytoplasm but can also function in the nucleus. Consequently, SIRT2 localisation and its interacting partners may greatly impact its function and need to be defined more clearly. In this study we used mass spectrometry to determine the interactomes of SIRT2 in whole cells ...[more]
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