Mycobacterium tuberculosis glycoproteomic
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast)
SUBMITTER: 
Emmanuelle Mouton Barbosa
LAB HEAD: Michel Rivière
PROVIDER: PXD012018 | Pride | 2021-09-08
REPOSITORIES: Pride
Publications
Potential Plasticity of the Mannoprotein Repertoire Associated to <i>Mycobacterium tuberculosis</i> Virulence Unveiled by Mass Spectrometry-Based Glycoproteomics.
Tonini Laure L Sadet Bashir B Stella Alexandre A Bouyssié David D Nigou Jérôme J Burlet-Schiltz Odile O Rivière Michel M
Molecules (Basel, Switzerland) 20200518 10
To date, <i>Mycobacterium tuberculosis</i> (Mtb) remains the world's greatest infectious killer. The rise of multidrug-resistant strains stresses the need to identify new therapeutic targets to fight the epidemic. We previously demonstrated that bacterial protein-<i>O-</i>mannosylation is crucial for Mtb infectiousness, renewing the interest of the bacterial-secreted mannoproteins as potential drug-targetable virulence factors. The difficulty of inventorying the mannoprotein repertoire expressed ...[more]
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