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Endogenous human milk proteolysis as a function of pH

ABSTRACT: The use of human milk products is increasing for high-risk infants. Human milk contains endogenous enzymes that comprise a dynamic proteolytic system; yet, biological properties of these enzymes and their activities in response to variations including pH within infants are unclear. This study was designed to determine the specificity of enzyme-substrate interactions in human milk as a function of pH.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Milk

SUBMITTER: Junai Gan

LAB HEAD: J. Bruce German

PROVIDER: PXD012748 | Pride | 2020-05-26

REPOSITORIES: Pride

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Selective Proteolysis of α-Lactalbumin by Endogenous Enzymes of Human Milk at Acidic pH.

Gan Junai J Zheng Jingyuan J Krishnakumar Nithya N Goonatilleke Elisha E Lebrilla Carlito B CB Barile Daniela D German J Bruce JB

Molecular nutrition & food research 20190716 18

<h4>Scope</h4>The use of human milk products is increasing for high-risk infants. Human milk contains endogenous enzymes that comprise a dynamic proteolytic system, yet biological properties of these enzymes and their activities in response to variations including pH within infants are unclear. Human milk has a neutral pH around 7, while infant gastric pH varies from 2 to 6 depending on individual conditions. This study is designed to determine the specificity of enzyme-substrate interactions in ...[more]

PMID: 31271254

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