Dataset Information

RsaC sRNA modulates the oxidative stress response of Staphylococcus aureus during manganese starvation.

ABSTRACT: The human opportunistic pathogen Staphylococcus aureus has developed multiple strategies to adapt to various environments, to fight and escape the immune system, to spread and persist in host tissues. It is responsible for numerous diseases ranging from benign skin infections to more serious such as endocarditis or septicemia. The pathogenicity is due to the production of a multitude of virulence factors, whose synthesis is finely regulated by a combination of regulatory proteins and small non-coding RNAs (sRNAs). Our study reveals an unexpected function of an atypical sRNA, RsaC, which is at the heart of networks controlling defence responses to oxidative stress, manganese import and nutrition immunity. This work highlights a novel mechanism required for S. aureus to survive into its host.

INSTRUMENT(S): TripleTOF 5600, Q Exactive

ORGANISM(S): Staphylococcus Aureus

SUBMITTER: Johana Chicher

LAB HEAD: David Lalaouna

PROVIDER: PXD013225 | Pride | 2019-11-11

REPOSITORIES: Pride

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Publications

RsaC sRNA modulates the oxidative stress response of Staphylococcus aureus during manganese starvation.

Lalaouna David D Baude Jessica J Wu Zongfu Z Tomasini Arnaud A Chicher Johana J Marzi Stefano S Vandenesch François F Romby Pascale P Caldelari Isabelle I Moreau Karen K

Nucleic acids research 20191001 18

The human opportunistic pathogen Staphylococcus aureus produces numerous small regulatory RNAs (sRNAs) for which functions are still poorly understood. Here, we focused on an atypical and large sRNA called RsaC. Its length varies between different isolates due to the presence of repeated sequences at the 5' end while its 3' part is structurally independent and highly conserved. Using MS2-affinity purification coupled with RNA sequencing (MAPS) and quantitative differential proteomics, sodA mRNA ...[more]

PMID: 31504767

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Dataset Information

RsaC sRNA modulates the oxidative stress response of Staphylococcus aureus during manganese starvation.

Publications

RsaC sRNA modulates the oxidative stress response of Staphylococcus aureus during manganese starvation.

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