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Phosphoproteomic analysis of estrogen signaling upstream and downstream of mTORC1

ABSTRACT: Phosphoproteomic data from human MCF-7 cells treated with estrogen only or estrogen plus rapamycin, an mTOR inhibitor.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Mcf-7 Cell

DISEASE(S): Breast Cancer

SUBMITTER: Matthew Monroe

LAB HEAD: Marina K. Holz

PROVIDER: PXD013503 | Pride | 2019-08-08

REPOSITORIES: Pride

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Publications

Phosphoproteome Analysis Reveals Estrogen-ER Pathway as a Modulator of mTOR Activity Via DEPTOR.

Cuesta Rafael R Gritsenko Marina A MA Petyuk Vladislav A VA Shukla Anil K AK Tsai Chia-Feng CF Liu Tao T McDermott Jason E JE Holz Marina K MK

Molecular & cellular proteomics : MCP 20190612 8

ER-positive breast tumors represent ∼70% of all breast cancer cases. Although their treatment with endocrine therapies is effective in the adjuvant or recurrent settings, the development of resistance compromises their effectiveness. The binding of estrogen to ERα, a transcription factor, triggers the regulation of the target genes (genomic pathway). Additionally, a cytoplasmic fraction of estrogen-bound ERα activates oncogenic signaling pathways such as PI3K/AKT/mTOR (nongenomic pathway). The u ...[more]

PMID: 31189691

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