Comparison of proteome alternations during aging in temporal lobe from human and rhesus macaque

ABSTRACT: Aging of population is a great challenge of healthcare. In china, the number of the elderly is rapidly growing, and it was estimated that there will be approximately 400 million citizens above 65 years old in 2050.Study on the changes of brain during aging may help elucidate the mechanism of the pathological process, and hence prevent or treat these neurological diseases.Rhesus macaque (Macaca mulatta) and human have a genetic homology of 95%, and their anatomy structures or physiological process are highly similar, which make rhesus macaque one of the most important nonhuman primate models.Thus, the comparison between the change of protein profile during aging in human and rhesus macaque is still necessary, and the characteristics of proteins that are conservative or divergent are of interest.The aim of the(our) study is to identify the conservative changes of pathways during aging, and to reveal the potential difference between human and rhesus macaque so that relevant studies based on primate models can be interpreted more accurately.

INSTRUMENT(S):

ORGANISM(S): Macaca Mulatta (rhesus Macaque)

TISSUE(S): Brain

SUBMITTER: Wei Ge  

LAB HEAD: Wei Ge

PROVIDER: PXD013597 | Pride | 2020-06-25

REPOSITORIES: Pride