Dataset Information
L-Bodies are Novel RNA-Protein Condensates Driving RNA Transport in Xenopus Oocytes
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Xenopus Laevis (african Clawed Frog)
TISSUE(S): Oocyte
SUBMITTER: 
Samantha Jeschonek
LAB HEAD: Samantha Jeschonek
PROVIDER: PXD013742 | Pride | 2020-03-20
REPOSITORIES: Pride
Publications
L-bodies are RNA-protein condensates driving RNA localization in <i>Xenopus</i> oocytes.
Molecular biology of the cell 20211006 22
Ribonucleoprotein (RNP) granules are membraneless compartments within cells, formed by phase separation, that function as regulatory hubs for diverse biological processes. However, the mechanisms by which RNAs and proteins interact to promote RNP granule structure and function in vivo remain unclear. In <i>Xenopus laevis</i> oocytes, maternal mRNAs are localized as large RNPs to the vegetal hemisphere of the developing oocyte, where local translation is critical for proper embryonic patterning. ...[more]
