Impairment of autophagic flux by combined EGFR and ROCK inhibition leads to triple-negative breast cancer cell death

ABSTRACT: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with very limited therapeutic options. We have recently shown that the combined inhibition of EGFR and ROCK in TNBC cells results in cell cycle arrest and ultimately cell death. However, the underlying mechanisms by which co-inhibition of EGFR and ROCK induces cell death remain unclear. To investigate the synergistic effect of the combination treatment on TNBC cells, in the present study we applied a mass spectrometry-based proteomic approach to identify proteins altered upon single and combination treatments.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

DISEASE(S): Breast Cancer

SUBMITTER: Stamatia Rontogianni  

LAB HEAD: A. F. Maarten Altelaar

PROVIDER: PXD013821 | Pride | 2019-12-04

REPOSITORIES: Pride