Proteomics,Multiomics

Dataset Information

6

The effects of fetal prenatal androgen and estrogenic exposure on the health of adult animals


ABSTRACT: Prenatal exposure to androgens and estrogens and their effect on liver development

OTHER RELATED OMICS DATASETS IN: E-MTAB-8032

INSTRUMENT(S): Q Exactive

ORGANISM(S): Ovis aries  

TISSUE(S): Liver

DISEASE(S): Not Available

SUBMITTER: Panagiotis Filis  

LAB HEAD: Mick Rae

PROVIDER: PXD014050 | Pride | 2020-01-09

REPOSITORIES: Pride

Dataset's files

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Publications

Fetal androgen exposure is a determinant of adult male metabolic health.

Siemienowicz Katarzyna J KJ   Filis Panagiotis P   Shaw Sophie S   Douglas Alex A   Thomas Jennifer J   Mulroy Sally S   Howie Forbes F   Fowler Paul A PA   Duncan W Colin WC   Rae Mick T MT  

Scientific reports 20191227 1


Androgen signalling is a critical driver of male development. Fetal steroid signalling can be dysregulated by a range of environmental insults and clinical conditions. We hypothesised that poor adult male health was partially attributable to aberrant androgen exposure during development. Testosterone was directly administered to developing male ovine fetuses to model excess prenatal androgenic overexposure associated with conditions such as polycystic ovary syndrome (PCOS). Such in utero androge  ...[more]

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