Proteomics

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Chr18 Consortium MS-data for missing proteins mining

ABSTRACT: Despite direct or indirect efforts of proteomic community, the fraction of blind spots on the protein map is still significant. Almost 10% (?) of human master protein has no experimental validation up to now. Apparently, proteomics has reached the stage where all easy scores are achieved (?), and every next identification requires more intension and curiosity in expansion of unusual types of biomaterial and/or conditions. In this article we discuss the current state of missing proteins search conducted by eclectic Russian Consortium in frame of C-HPP. We accumulated various data, obtained by Russian Proteomic Consortium.

INSTRUMENT(S): LTQ Orbitrap Elite, Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Adipocyte, Brain, Cardiomyocyte Cell Line, Placenta, Blood Plasma, Caco-2 Cell, Hepg2 Cell, Cell Culture, Cervicovaginal Fluid, Hela Cell

DISEASE(S): Cardiovascular System Disease,Glioblastoma

SUBMITTER: Ekaterina Ilgisonis  

LAB HEAD: Elena Alexandrovna Ponomarenko

PROVIDER: PXD014300 | Pride | 2020-06-03

REPOSITORIES: Pride

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Publications

Is It Possible to Find Needles in a Haystack? Meta-Analysis of 1000+ MS/MS Files Provided by the Russian Proteomic Consortium for Mining Missing Proteins.

Poverennaya Ekaterina E   Kiseleva Olga O   Ilgisonis Ekaterina E   Novikova Svetlana S   Kopylov Arthur A   Ivanov Yuri Y   Kononikhin Alexei A   Gorshkov Mikhail M   Kushlinskii Nikolay N   Archakov Alexander A   Ponomarenko Elena E  

Proteomes 20200523 2

Despite direct or indirect efforts of the proteomic community, the fraction of blind spots on the protein map is still significant. Almost 11% of human genes encode missing proteins; the existence of which proteins is still in doubt. Apparently, proteomics has reached a stage when more attention and curiosity need to be exerted in the identification of every novel protein in order to expand the unusual types of biomaterials and/or conditions. It seems that we have exhausted the current conventio  ...[more]

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