Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Brain, Microglial Cell
SUBMITTER: Allan Stensballe
LAB HEAD: Allan Stensballe
PROVIDER: PXD015939 | Pride | 2020-06-29
REPOSITORIES: Pride
Martin Nellie A NA Hyrlov Kirsten H KH Elkjaer Maria L ML Thygesen Eva K EK Wlodarczyk Agnieszka A Elbaek Kirstine J KJ Aboo Christopher C Okarmus Justyna J Benedikz Eirikur E Reynolds Richard R Hegedus Zoltan Z Stensballe Allan A Svenningsen Åsa Fex ÅF Owens Trevor T Illes Zsolt Z
Frontiers in immunology 20200605
<b>Background:</b> MiR-146a is an important regulator of innate inflammatory responses and is also implicated in cell death and survival. <b>Methods:</b> By sorting CNS resident cells, microglia were the main cellular source of miR-146a. Therefore, we investigated microglia function and phenotype in miR-146a knock-out (KO) mice, analyzed the proteome of KO and wild-type (WT) microglia by LC-MS/MS, and examined miR-146a expression in different brain lesions of patients with multiple sclerosis (MS ...[more]