Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Erythrocyte, Cell Culture, Blood
SUBMITTER: Mario Oroshi
LAB HEAD: Matthias Mann
PROVIDER: PXD017276 | Pride | 2020-10-20
REPOSITORIES: Pride
Molecular systems biology 20201201 12
Human erythropoiesis is an exquisitely controlled multistep developmental process, and its dysregulation leads to numerous human diseases. Transcriptome and epigenome studies provided insights into system-wide regulation, but we currently lack a global mechanistic view on the dynamics of proteome and post-translational regulation coordinating erythroid maturation. We established a mass spectrometry (MS)-based proteomics workflow to quantify and dynamically track 7,400 proteins and 27,000 phospho ...[more]