Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos, Q Exactive Plus
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Tomi Määttä
LAB HEAD: Mikhail M Savitski
PROVIDER: PXD017291 | Pride | 2020-09-22
REPOSITORIES: Pride
Määttä Tomi A TA Rettel Mandy M Sridharan Sindhuja S Helm Dominic D Kurzawa Nils N Stein Frank F Savitski Mikhail M MM
Molecular systems biology 20201001 10
Protein aggregates have negative implications in disease. While reductionist experiments have increased our understanding of aggregation processes, the systemic view in biological context is still limited. To extend this understanding, we used mass spectrometry-based proteomics to characterize aggregation and disaggregation in human cells after non-lethal heat shock. Aggregation-prone proteins were enriched in nuclear proteins, high proportion of intrinsically disordered regions, high molecular ...[more]