Dataset Information


Transcriptional profiling of Caenorhabditis elegans and Caenorhabditis briggsae before and after heat shock

ABSTRACT: Transcriptional profiling of heat-shocked worms was compared to non-heat-shocked worms to determine genes that are induced upon heat shock in each species; heat-shock-induced genes in each species were compared Overall design: 3 biological replicates were performed for both control (NHS) and heat-shocked (HS) worms of each species giving a total of 12 samples

INSTRUMENT(S): Illumina HiSeq 4000 (Caenorhabditis elegans)

SUBMITTER: Jacob Garrigues 

PROVIDER: GSE135987 | GEO | 2019-12-17


Dataset's files

Action DRS
GSE135987_Cbr_AF16_NHS.HS_normalized.counts.txt.gz Txt
GSE135987_Cel_N2_NHS.HS_normalized.counts.txt.gz Txt
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Diversification of the <i>Caenorhabditis</i> heat shock response by Helitron transposable elements.

Garrigues Jacob M JM   Tsu Brian V BV   Daugherty Matthew D MD   Pasquinelli Amy E AE  

eLife 20191211

Heat Shock Factor 1 (HSF-1) is a key regulator of the heat shock response (HSR). Upon heat shock, HSF-1 binds well-conserved motifs, called Heat Shock Elements (HSEs), and drives expression of genes important for cellular protection during this stress. Remarkably, we found that substantial numbers of HSEs in multiple <i>Caenorhabditis</i> species reside within Helitrons, a type of DNA transposon. Consistent with Helitron-embedded HSEs being functional, upon heat shock they display increased HSF-  ...[more]

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