Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Fibroblast
SUBMITTER: Mark Parthun
LAB HEAD: Mark Robert Parthun
PROVIDER: PXD017362 | Pride | 2020-02-28
REPOSITORIES: Pride
Agudelo Garcia Paula A PA Nagarajan Prabakaran P Parthun Mark R MR
Journal of proteome research 20200304 4
Lysine acetylation has emerged as one of the most important post-translational modifications, regulating different biological processes. However, its regulation by lysine acetyltransferases is still unclear in most cases. Hat1 is a lysine acetyltransferase originally identified based on its ability to acetylate histones. Using an unbiased proteomics approach, we have determined how loss of Hat1 affects the mammalian acetylome. Hat1<sup>+/+</sup> and Hat1<sup>-/-</sup> mouse embryonic fibroblast ...[more]