Spinal cord phosphoproteome of SCA2/ALS13 mouse model

ABSTRACT: Toxic polyglutamine (polyQ) expansions in ATXN2 trigger neurodegenerative processes, causing Spinocerebellar Ataxia type 2 (SCA2), and enhancing TDP 43-dependent pathology in Amyotrophic Lateral Sclerosis (ALS) / Fronto-Temporal Dementia (FTD). Primary disease events can be compensated transiently, delaying disease manifestation. To define potential therapy targets, we documented how cells modify their phospho-signals and how the ATXN2 interactome changes, using preferentially affected nervous tissues from end-stage Atxn2-CAG100-KnockIn mice.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Spinal Cord

SUBMITTER: Jana Key  

LAB HEAD: Georg Auburger

PROVIDER: PXD062823 | Pride | 2025-09-29

REPOSITORIES: Pride