Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture, Fibroblast
SUBMITTER: Rosemary O'Connor
LAB HEAD: Rosemary O'Connor
PROVIDER: PXD017644 | Pride | 2020-05-15
REPOSITORIES: Pride
Rieger Leonie L O'Shea Sandra S Godsmark Grant G Stanicka Joanna J Kelly Geraldine G O'Connor Rosemary R
Science signaling 20200526 633
Although insulin-like growth factor 1 (IGF-1) signaling promotes tumor growth and cancer progression, therapies that target the IGF-1 receptor (IGF-1R) have shown poor clinical efficacy. To address IGF-1R activity in cancer cells and how it differs from that of the closely related insulin receptor (IR), we focused on two tyrosines in the IGF-1R C-terminal tail that are not present in the IR and are essential for IGF-1-mediated cancer cell survival, migration, and tumorigenic growth. We found tha ...[more]