Proteomics

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Characterization of PITH domain-containing protein 1 (C1orf128) functionality in olfactory metabolism

ABSTRACT: Taking into account the relevance of the smell sense in the early diagnosis of neurodegenerative diseases, we have analyzed the expression profile of the dark proteome across public proteomic and transcriptomic data derived from primary olfactory areas such as olfactory bulb (OB) and cleft mucus as well as from specific brain/OB cell linages. In this study, we have used an experimental workflow combining neuropathological diagnosis, co-regulation maps, physical and functional interaction data, transgenic models, intracellular and extracellular proteomics and immunohistochemical and biochemical approaches to partially decipher the UPE1 PITHD1 function in olfactory metabolism.

INSTRUMENT(S): timsTOF Pro

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Mikel Azkargorta  

LAB HEAD: Felix Elortza

PROVIDER: PXD018784 | Pride | 2020-11-19

REPOSITORIES: Pride

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Publications

Smelling the Dark Proteome: Functional Characterization of PITH Domain-Containing Protein 1 (C1orf128) in Olfactory Metabolism.

Lachén-Montes Mercedes M   Mendizuri Naroa N   Ausín Karina K   Pérez-Mediavilla Alberto A   Azkargorta Mikel M   Iloro Ibon I   Elortza Felix F   Kondo Hiroyuki H   Ohigashi Izumi I   Ferrer Isidre I   de la Torre Rafael R   Robledo Patricia P   Fernández-Irigoyen Joaquín J   Santamaría Enrique E  

Journal of proteome research 20201113 12

The Human Proteome Project (HPP) consortium aims to functionally characterize the dark proteome. On the basis of the relevance of olfaction in early neurodegeneration, we have analyzed the dark proteome using data mining in public resources and omics data sets derived from the human olfactory system. Multiple dark proteins localize at synaptic terminals and may be involved in amyloidopathies such as Alzheimer's disease (AD). We have characterized the dark PITH domain-containing protein 1 (PITHD1  ...[more]

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