Proteomics

Dataset Information

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Identification of serum-based biomarkers in oral cancer among tobacco users

ABSTRACT: Oral cancer is the leading cancer worldwide with significant morbidity and mortality rate. Use of tobacco in form of both chewing and smoking have been known as major risk factors along with alcohol and HPV infection. Despite such knowledge, there are yet no proper screening strategy employed for screening of oral cancer at early stage. In this study, we employed TMT-based comparison of proteins from serum samples from healthy volunteers and OSCC patients with chewing and smoking habits. The data has been acquired in triplicate where we have used multiple fractionation strategies such as bRPLC and SCX-based fractionation. The candidate proteins identified at discovery phase were further validated using ELISA.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Serum

DISEASE(S): Oral Squamous Cell Carcinoma

SUBMITTER: Keshava Prasad T. S.  

LAB HEAD: T. S. Keshava Prasad

PROVIDER: PXD019014 | Pride | 2026-04-27

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
OSCC_Chewer_SCX.msf Msf
OSCC_Chewer_SCX1_R1.raw Raw
OSCC_Chewer_SCX1_R2.raw Raw
OSCC_Chewer_SCX1_R3.raw Raw
OSCC_Chewer_SCX2_R1.raw Raw
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Publications

Molecular alterations in oral cancer between tobacco chewers and smokers using serum proteomics.

Mohanty Varshasnata V   Subbannayya Yashwanth Y   Patil Shankargouda S   Abdulla Riaz R   Ganesh Mandakulutur S MS   Pal Arnab A   Ray Jay Gopal JG   Sidransky David D   Gowda Harsha H   Prasad T S Keshava TSK   Chatterjee Aditi A  

Cancer biomarkers : section A of Disease markers 20210101 4

<h4>Background</h4>Tobacco exposure (through smoking or chewing) is one of the predominant risk factors associated with the development of oral squamous cell carcinoma (OSCC). Despite the growing number of patients diagnosed with OSCC, there are few circulating biomarkers for identifying individuals at a higher risk of developing the disease. Successful identification of candidate molecular markers for risk assessment could aid in the early detection of oral lesions and potentially be used for c  ...[more]

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