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Proteome profilling of chromophobe renal cell carcinomas

ABSTRACT: LC-MS/MS based proteomics study of chromophobe renal cell carcinomas versus the adjacent healthy kidney tissues, nine patients included. The chromophobe renal cell carcinoma cells (UOK276) under different conditions were also analyzed.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell, Chromophobe Renal Cell Carcinoma Cell, Kidney

DISEASE(S): Chromophobe Renal Cell Carcinoma

SUBMITTER: Yi Xiao

LAB HEAD: David Meierhofer

PROVIDER: PXD019123 | Pride | 2020-07-23

REPOSITORIES: Pride

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Decreased Mitochondrial DNA Content Drives OXPHOS Dysregulation in Chromophobe Renal Cell Carcinoma.

Xiao Yi Y Clima Rosanna R Busch Jonas J Rabien Anja A Kilic Ergin E Villegas Sonia L SL Timmermann Bernd B Attimonelli Marcella M Jung Klaus K Meierhofer David D

Cancer research 20200721 18

Chromophobe renal cell carcinoma (chRCC) and renal oncocytoma are closely related, rare kidney tumors. Mutations in complex I (CI)-encoding genes play an important role in dysfunction of the oxidative phosphorylation (OXPHOS) system in renal oncocytoma, but are less frequently observed in chRCC. As such, the relevance of OXPHOS status and role of CI mutations in chRCC remain unknown. To address this issue, we performed proteome and metabolome profiling as well as mitochondrial whole-exome sequen ...[more]

PMID: 32694149

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