Ontology highlight
ABSTRACT:
INSTRUMENT(S): TripleTOF 5600
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Lei Zhou
LAB HEAD: Lei Zhou
PROVIDER: PXD019694 | Pride | 2021-09-09
REPOSITORIES: Pride
Liu Jingshu J Qiu Jiangfeng J Zhang Zhiqi Z Zhou Lei L Li Yunzhe Y Ding Dongyan D Zhang Yang Y Zou Dongling D Wang Dong D Zhou Qi Q Lang Tingyuan T
Cell & bioscience 20210122 1
<h4>Background</h4>Cancer stem cells (CSCs) are the root of human cancer development and the major cause of treatment failure. Aberrant elevation of SOX4, a member of SOX (SRY-related HMG-box) family transcription factors, has been identified in many types of human cancer and promotes cancer development. However, the role of SOX4 in CSCs, especially at a proteome-wide level, has remained elusive. The aim of this study is to investigate the effect of SOX4 on the stemness of CSCs and reveal the un ...[more]